With the rising cases in the second wave of COVID-19 pandemic the challenges faced by health systems in delivering essential healthcare are growing. Based on the guidelines of MoHFW, majority of COVID-19 cases who are mild or asymptomatic are resorting to home isolation. However, follow-up of these home isolated cases becomes pertinent to further avoid complications. Given the magnitude of cases currently under home isolation, technology-based solutions provide the way forward to monitor all patients. In this view, USAID funded project NISHTHA has established a comprehensive home-based care model, to support state Governments of Arunachal Pradesh, Madhya Pradesh, Meghalaya, Mizoram and Nagaland to provide end-to-end care to home-isolated COVID-19 cases. To operationalize this model, NISHTHA has partnered with Karma Healthcare as a technology and implementation partner. The model aims to develop a robust end to end mechanism to follow up with home isolated patient, strengthen monitoring and tracking of such patients by providing teleconsultations with specialists throughout their period of home isolation. The model will also enable early identification and referral of severe patients thus reducing mortality due to COVID.